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Scanning Electron Microscope (SEM) image of amphotericin B-loaded (AmphB-loaded) nanofibers. Samples prepared from AmphB/gamma-cyclodextrin (γ-CD)/polyvinyl alcohol (PVA)/sodium <t>taurocholate</t> (STC). (magnification: 5000×). All samples contained PVA (12% w / w ) and AmphB (0.03% w / w ). ( F1 – F3 ) 5% γ-CD with 1–3% STC; ( F4 – F6 ) 7.5% γ-CD with 1–3% STC; ( F7 – F9 ) 10% γ-CD with 1, 2 and 3% STC.
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Scanning Electron Microscope (SEM) image of amphotericin B-loaded (AmphB-loaded) nanofibers. Samples prepared from AmphB/gamma-cyclodextrin (γ-CD)/polyvinyl alcohol (PVA)/sodium <t>taurocholate</t> (STC). (magnification: 5000×). All samples contained PVA (12% w / w ) and AmphB (0.03% w / w ). ( F1 – F3 ) 5% γ-CD with 1–3% STC; ( F4 – F6 ) 7.5% γ-CD with 1–3% STC; ( F7 – F9 ) 10% γ-CD with 1, 2 and 3% STC.
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Scanning Electron Microscope (SEM) image of amphotericin B-loaded (AmphB-loaded) nanofibers. Samples prepared from AmphB/gamma-cyclodextrin (γ-CD)/polyvinyl alcohol (PVA)/sodium taurocholate (STC). (magnification: 5000×). All samples contained PVA (12% w / w ) and AmphB (0.03% w / w ). ( F1 – F3 ) 5% γ-CD with 1–3% STC; ( F4 – F6 ) 7.5% γ-CD with 1–3% STC; ( F7 – F9 ) 10% γ-CD with 1, 2 and 3% STC.

Journal: Pharmaceutics

Article Title: Development and Formulation of Nanofiber-Based Ophthalmic Inserts for the Treatment of Fungal Keratitis

doi: 10.3390/pharmaceutics18040464

Figure Lengend Snippet: Scanning Electron Microscope (SEM) image of amphotericin B-loaded (AmphB-loaded) nanofibers. Samples prepared from AmphB/gamma-cyclodextrin (γ-CD)/polyvinyl alcohol (PVA)/sodium taurocholate (STC). (magnification: 5000×). All samples contained PVA (12% w / w ) and AmphB (0.03% w / w ). ( F1 – F3 ) 5% γ-CD with 1–3% STC; ( F4 – F6 ) 7.5% γ-CD with 1–3% STC; ( F7 – F9 ) 10% γ-CD with 1, 2 and 3% STC.

Article Snippet: Sodium taurocholate (STC, was the product of TCI Ltd. (Tokyo, Japan)).

Techniques: Microscopy

Fourier transform infrared (FTIR) spectra of the amphotericin B-loaded (AmphB-loaded) fibers. Where AmphB: amphotericin B; PVA: (polyvinyl alcohol, Mw ~130 kDa); STC: sodium taurocholate; γ-CD: gamma-cyclodextrin; PM: physical mixture; NF: nanofibers.

Journal: Pharmaceutics

Article Title: Development and Formulation of Nanofiber-Based Ophthalmic Inserts for the Treatment of Fungal Keratitis

doi: 10.3390/pharmaceutics18040464

Figure Lengend Snippet: Fourier transform infrared (FTIR) spectra of the amphotericin B-loaded (AmphB-loaded) fibers. Where AmphB: amphotericin B; PVA: (polyvinyl alcohol, Mw ~130 kDa); STC: sodium taurocholate; γ-CD: gamma-cyclodextrin; PM: physical mixture; NF: nanofibers.

Article Snippet: Sodium taurocholate (STC, was the product of TCI Ltd. (Tokyo, Japan)).

Techniques: Fourier Transform Infrared Spectroscopy

X-ray Diffraction (XRD) pattern of amphotericin B-loaded (Am-phB-loaded) nanofibers. The diffraction peaks correspond to the crystalline AmphB, physical mixture (PM), and AmphB-loaded nanofibers (F3, F6, and F9). The components for PM, F3, F6, and F9 are AmphB/gamma-cyclodextrin (γ-CD)/polyvinyl alcohol (PVA)/sodium taurocholate (STC). F3 has 5% γ-CD and 3% STC, F6 has 7.5% γ-CD and 3% STC, and F9 has 10% γ-CD and 3% STC. The reduced or absent crystalline peaks in the nanofibers indicate amorphization of AmphB. The XRD analysis confirms the successful amorphization of crystalline AmphB.

Journal: Pharmaceutics

Article Title: Development and Formulation of Nanofiber-Based Ophthalmic Inserts for the Treatment of Fungal Keratitis

doi: 10.3390/pharmaceutics18040464

Figure Lengend Snippet: X-ray Diffraction (XRD) pattern of amphotericin B-loaded (Am-phB-loaded) nanofibers. The diffraction peaks correspond to the crystalline AmphB, physical mixture (PM), and AmphB-loaded nanofibers (F3, F6, and F9). The components for PM, F3, F6, and F9 are AmphB/gamma-cyclodextrin (γ-CD)/polyvinyl alcohol (PVA)/sodium taurocholate (STC). F3 has 5% γ-CD and 3% STC, F6 has 7.5% γ-CD and 3% STC, and F9 has 10% γ-CD and 3% STC. The reduced or absent crystalline peaks in the nanofibers indicate amorphization of AmphB. The XRD analysis confirms the successful amorphization of crystalline AmphB.

Article Snippet: Sodium taurocholate (STC, was the product of TCI Ltd. (Tokyo, Japan)).

Techniques: